Increase knowledge and understanding of irritable bowel syndrome.

Our primary objective is a multidisciplinary approach to increase knowledge and understanding of irritable bowel syndrome and explore treatment strategies related to diet.

The secondary objectives are addressing the multifaceted manifestations of IBS symptoms.
– Identify and quantify structural and functional brain connectivity signatures and gastrointestinal motility patterns in IBS patients using advanced neuro and abdominal imaging and the Rome IV classification criteria.
– Assess cognition in multiple cognitive domains in IBS patients and compare with imaging and symptom scores.
– Stool samples for microbiota DNA analyses, and blood samples for measurement of short-chain fatty acids, pancreatic polypeptide YY and genetic profiling.
– Define phenotypes and biomarkers from our data using high dimensional data-driven and machine learning techniques.
– Employ clinical and cognitive scores with biomarker trajectories to assess treatment effects of low-FODMAP diet.